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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SYK
All Species:
25.45
Human Site:
S174
Identified Species:
56
UniProt:
P43405
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43405
NP_001128524.1
635
72066
S174
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
Chimpanzee
Pan troglodytes
XP_520123
544
61880
H124
L
H
E
G
K
V
L
H
Y
R
I
D
K
D
K
Rhesus Macaque
Macaca mulatta
XP_001100834
635
72070
S174
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
Dog
Lupus familis
XP_850411
644
73172
S173
P
W
F
H
G
K
I
S
R
V
E
S
E
Q
I
Cat
Felis silvestris
Mouse
Mus musculus
P48025
629
71358
S173
P
W
F
H
G
N
I
S
R
D
E
S
E
Q
T
Rat
Rattus norvegicus
Q64725
629
71510
S173
P
W
F
H
G
N
I
S
R
D
E
S
E
Q
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026601
613
69811
S173
P
W
F
H
G
R
I
S
R
E
E
S
E
H
R
Frog
Xenopus laevis
NP_001083616
609
69575
S169
P
W
F
H
G
R
I
S
R
E
D
S
E
Q
L
Zebra Danio
Brachydanio rerio
NP_998008
586
67629
G166
E
K
M
P
W
F
H
G
K
I
D
R
E
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24145
939
104255
T318
A
K
Q
P
E
V
D
T
S
G
C
F
L
V
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180232
837
93621
D357
P
W
F
H
G
S
M
D
R
K
K
A
L
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.5
99
91.1
N.A.
92.1
91
N.A.
N.A.
77.4
67.7
65.9
N.A.
25.5
N.A.
N.A.
26.5
Protein Similarity:
100
85.6
99.5
94.4
N.A.
94.4
93.6
N.A.
N.A.
87.4
79
77.4
N.A.
39.9
N.A.
N.A.
40.7
P-Site Identity:
100
0
100
93.3
N.A.
80
80
N.A.
N.A.
80
80
6.6
N.A.
0
N.A.
N.A.
40
P-Site Similarity:
100
13.3
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
86.6
100
20
N.A.
6.6
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
10
0
19
19
10
0
19
0
% D
% Glu:
10
0
10
0
10
0
0
0
0
37
55
0
73
10
0
% E
% Phe:
0
0
73
0
0
10
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
0
10
73
0
0
10
0
10
0
0
0
0
0
% G
% His:
0
10
0
73
0
0
10
10
0
0
0
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
64
0
0
10
10
0
0
0
28
% I
% Lys:
0
19
0
0
10
28
0
0
10
10
10
0
10
0
10
% K
% Leu:
10
0
0
0
0
0
10
0
0
0
0
0
19
0
10
% L
% Met:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
19
0
0
0
0
0
0
0
0
0
% N
% Pro:
73
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
0
0
0
55
0
% Q
% Arg:
0
0
0
0
0
19
0
0
73
10
0
10
0
0
19
% R
% Ser:
0
0
0
0
0
10
0
64
10
0
0
64
0
0
19
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
19
% T
% Val:
0
0
0
0
0
19
0
0
0
10
0
0
0
10
0
% V
% Trp:
0
73
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _